I started off using the Now Theme from Themer and tweaked it until it took a life of its own.
The images change every 5 seconds using the Animated Photo Frame Widget. I can cycle through my whole wallpaper collection easily. The main screen has all my main apps inside folders. The App Launcher is the gray button, as well as a "Slide Up" gesture. The 2nd screen has a TV Show Favs widget to keep track of my TV shows.